PROTAC BRD4 Degrader-11

PROTAC BRD4 Degrader-11

• UNSPSC Description: PROTAC BRD4 Degrader-11 (compound 9a) is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-11 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.23 nM and 0.38 nM, respectively[1].
• Target Antigen: Epigenetic Reader Domain; PROTACs
• Type: ADC Related
• Related Pathways: Epigenetics;PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-brd4-degrader-11.html
• Smiles: CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@H](CN3C([C@@H](NC(CCCCCCCCCCNC(C4=CC(N(C5=NC=C(F)C=C5F)CC6=CNC7=C6C8=CN(C)C7=O)=C8C=C4CS(=O)(C)=O)=O)=O)C(C)(C)C)=O)OC(OC[C@@H](C)SS(C)(=O)=O)=O)=O)C=C2
• Molecular Weight: 1292.56
• References & Citations: [1]Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.
• Shipping Conditions: Blue Ice