HDAC6-IN-36

• Description:

  HDAC6-IN-36 (compound 11d) is an inhibitor of HDAC6 with IC50 value of 8.64 nM. HDAC6-IN-36 induces neurite outgrowth of PC12 cells without producing toxic effects.

• UNSPSC:

  12352005

• Target:

  HDAC

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/hdac6-in-36.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NCC1=CC=C(C(NO)=O)C=C1)[C@H](C2)N(CC3CC3)[C@H](C4=CC=C(Cl)C=C4)C5=C2C6=CC=CC=C6N5

• Molecular Formula:

  C30H29ClN4O3

• Molecular Weight:

  529.03

• References & Citations:

  [1]Wen Wen , et al. Re-exploration of tetrahydro-β-carboline scaffold: Discovery of selective histone deacetylase 6 inhibitors with neurite outgrowth-promoting and neuroprotective activities. Bioorg Med Chem Lett. 2024.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HDAC1; HDAC6