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ONO-7579

CAT: 0804-HY-164517Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-164517Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ONO-7579 is an orally active TRKA inhibitor that suppresses tumor growth by inhibiting the phosphorylation of TRKA. In colorectal cancer cells KM12, its EC50 is 17.6 ng/g (meaning that when each gram of tumor tissue contains 17.6 ng of ONO-7579, the activity of phosphorylated TRKA in the tumor is inhibited by 50%) . ONO-7579 can be used in cancer research[1].
CAS Number
1622212-25-2
UNSPSC
12352005
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ono-7579.html
Smiles
O=C(NC1=CC(C(F)(F)F)=CC=C1S(=O)(C)=O)NC2=CN=C(OC3=CC=C(C4=CC(Cl)=CN=C4N)C=C3)N=C2
Molecular Formula
C24H18ClF3N6O4S
Molecular Weight
578.95
References & Citations
[1]Iida H, et al. Pharmacokinetic-Pharmacodynamic-Efficacy Modeling of ONO-7579, a Novel Pan-Tropomyosin Receptor Kinase Inhibitor, in a Murine Xenograft Tumor Model. J Pharmacol Exp Ther. 2020 Jun;373 (3) :361-369.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
TrkA

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