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SR-3306

CAT: 0804-HY-12829-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12829-01Size:5 mg
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Description
SR-3306 is a selective, potent, highly brain penetrant JNK inhibitor.
CAS Number
[1128096-91-2]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
JNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/SR-3306.html
Purity
99.0
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC(C=C1)=NC=C1C2=NN(C=N2)C3=CC=C(NC4=NC=CC(C5=CC=CC(N6CCOCC6)=C5)=N4)C=C3
Molecular Formula
C28H26N8O
Molecular Weight
490.56
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Crocker CE, et al. JNK Inhibition Protects Dopamine Neurons and Provides Behavioral Improvement in a Rat 6-hydroxydopamine Model of Parkinson's Disease. ACS Chem Neurosci. 2011 Apr 20;2 (4) :207-212.|[2]Chambers JW, et al. Inhibition of JNK mitochondrial localization and signaling is protective against ischemia/reperfusion injury in rats. J Biol Chem. 2013 Feb 8;288 (6) :4000-11.|[3]Gao S, et al. Pharmacological Inhibition of c-Jun N-terminal Kinase Reduces Food Intake and Sensitizes Leptin's Anorectic Signaling Actions. Sci Rep. 2017 Feb 6;7:41795.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JNK

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