ACT-462206

• Description :

  ACT-462206 is an orally active and potent dual Orexin 1/Orexin 2 receptor antagonist with IC50s of 60 nM (Orexin 1) and 11 nM (Orexin 2), respectively. ACT-462206 exhibits brain penetration properties, and can be used for insomnia, stress/anxiety-related disorders and addiction research[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Orexin Receptor (OX Receptor)

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/act-462206.html

• Purity :

  99.54

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C([C@H]1N(S(=O)(C2=CC=C(OC)C=C2)=O)CCC1)NC3=CC(C)=CC(C)=C3

• Molecular Formula :

  C20H24N2O4S

• Molecular Weight :

  388.48

• Precautions :

  H302

• References & Citations :

  [1]Boss C, et al. Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist. ChemMedChem. 2014 Nov;9 (11) :2486-96.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  OX1 Receptor; OX2 Receptor

• CAS Number :

  [1361321-96-1]