ACT-462206

CAT: 0804-HY-101834-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-101834-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
ACT-462206 is an orally active and potent dual Orexin 1/Orexin 2 receptor antagonist with IC50s of 60 nM (Orexin 1) and 11 nM (Orexin 2), respectively. ACT-462206 exhibits brain penetration properties, and can be used for insomnia, stress/anxiety-related disorders and addiction research[1].
CAS Number
[1361321-96-1]
UNSPSC
12352005
Hazard Statement
H302
Target
Orexin Receptor (OX Receptor)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/act-462206.html
Purity
99.54
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C([C@H]1N(S(=O)(C2=CC=C(OC)C=C2)=O)CCC1)NC3=CC(C)=CC(C)=C3
Molecular Formula
C20H24N2O4S
Molecular Weight
388.48
Precautions
H302
References & Citations
[1]Boss C, et al. Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist. ChemMedChem. 2014 Nov;9 (11) :2486-96.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
OX1 Receptor; OX2 Receptor

Related Products

CatalogName
HY-124071-01ACT-389949
HY-153240ACT-672125
HY-119085ACT-281959
HY-108683ACT-335827
HY-135500-01ACT-373898
HY-149055-01ACT-777991
HY-111817-01ACT-451840
HY-U00262ACT 178882
HY-12616ACT-209905
HY-118036ACT-387042

Alternative Products

CatalogName
BA5667-25ACT-462206
5319/50ACT 462206
YP-W16964-01Human ACT (ACT) ELISA Kit
MBS132402-01Macitentan (ACT 064992; ACT-064992)
MBS3613109-01ACT-389949
M12099-01ACT-541468
MBS3840044-01ACT-335827
4983/10ACT 335827
MBS5776286ACT-209905
MBS5765572ACT-678689

Popular Products