ACT 178882

CAT: 0804-HY-U00262Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-U00262Size:1 Each
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Description
ACT 178882 is a new Renin inhibitor with an IC50 of 1.4 nM.
CAS Number
[1007392-69-9]
UNSPSC
12352005
Target
Renin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ACT_178882.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1CNCC[C@@H]1C2=CC=C(OCCOC3=C(Cl)C=C(C)C=C3Cl)N=C2)N(CC4=CC(CCOC)=CC=C4Cl)C5CC5
Molecular Formula
C33H38Cl3N3O4
Molecular Weight
647.03
References & Citations
[1]Corminboeuf O, et al. Piperidine-based renin inhibitors: upper chain optimization. Bioorg Med Chem Lett. 2010 Nov 1;20 (21) :6291-6.|[2]Dingemanse J, et al. Drug-drug interaction study of ACT-178882, a new renin inhibitor, and diltiazem in healthy subjects. Clin Drug Investig. 2013 Mar;33 (3) :207-13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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