ACT-373898

• Description :

  ACT-373898 is an inactive carboxylic acid metabolite of Macitentan. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Endothelin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/act-373898.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(O)COC1=NC=NC(NS(=O)(NCCC)=O)=C1C2=CC=C(Br)C=C2

• Molecular Formula :

  C15H17BrN4O5S

• Molecular Weight :

  445.29

• Precautions :

  P264-P270-P330-P501

• References & Citations :

  [1]Shirin Bruderer, et al. Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist. AAPS J. 2012 Mar;14 (1) :68-78.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ETA; ETB

• CAS Number :

  [1433875-14-9]