ACT-373898

• UNSPSC Description:

  ACT-373898 is an inactive carboxylic acid metabolite of Macitentan. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist[1].

• Target Antigen:

  Endothelin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/act-373898.html

• Smiles:

  O=C(O)COC1=NC=NC(NS(=O)(NCCC)=O)=C1C2=CC=C(Br)C=C2

• Molecular Weight:

  445.29

• References & Citations:

  [1]Shirin Bruderer, et al. Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist. AAPS J. 2012 Mar;14(1):68-78.

• Shipping Conditions:

  Room temperature

• CAS Number:

  1433875-14-9