ACT-672125

• UNSPSC Description:

  ACT-672125 is a potent CXCR3 antagonist with IC50 value of 239 nM in human blood. ACT-672125 has activity for hERG with IC50 value of 18μM. ACT-672125 can be used for the research of autoimmune diseases[1].

• Target Antigen:

  CXCR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/act-672125.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC(F)(C1=NC(C2=NC3=CC=C(C4=NOC(C)=N4)C=C3N2)=C(N5C[C@H](N(CC5)C(CN6C(C)=NC(C)=N6)=O)C)S1)F

• Molecular Weight:

  586.59

• References & Citations:

  [1]Caroff E, et al. Design, Synthesis, and Pharmacological Evaluation of Benzimidazolo-thiazoles as Potent CXCR3 Antagonists with Therapeutic Potential in Autoimmune Diseases: Discovery of ACT-672125. J Med Chem. 2022 Sep 8;65(17):11533-11549.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1449367-94-5