ACT-672125

CAT: 0804-HY-153240Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-153240Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
ACT-672125 is a potent CXCR3 antagonist with IC50 value of 239 nM in human blood. ACT-672125 has activity for hERG with IC50 value of 18μM. ACT-672125 can be used for the research of autoimmune diseases[1].
CAS Number
[1449367-94-5]
UNSPSC
12352005
Target
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/act-672125.html
Solubility
10 mM in DMSO
Smiles
FC(F)(C1=NC(C2=NC3=CC=C(C4=NOC(C)=N4)C=C3N2)=C(N5C[C@H](N(CC5)C(CN6C(C)=NC(C)=N6)=O)C)S1)F
Molecular Formula
C25H25F3N10O2S
Molecular Weight
586.59
References & Citations
[1]Caroff E, et al. Design, Synthesis, and Pharmacological Evaluation of Benzimidazolo-thiazoles as Potent CXCR3 Antagonists with Therapeutic Potential in Autoimmune Diseases: Discovery of ACT-672125. J Med Chem. 2022 Sep 8;65 (17) :11533-11549.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-124071-01ACT-389949
HY-101834-01ACT-462206
HY-119085ACT-281959
HY-108683ACT-335827
HY-135500-01ACT-373898
HY-149055-01ACT-777991
HY-111817-01ACT-451840
HY-U00262ACT 178882
HY-12616ACT-209905
HY-118036ACT-387042

Alternative Products

CatalogName
MBS5813155ACT-672125
YP-W16964-01Human ACT (ACT) ELISA Kit
MBS132402-01Macitentan (ACT 064992; ACT-064992)
MBS3613109-01ACT-389949
M12099-01ACT-541468
MBS3840044-01ACT-335827
4983/10ACT 335827
MBS5765572ACT-678689
MBS5776286ACT-209905
571533ACT-451840

Popular Products