NBI-34041

• Description:

  NBI-34041 (SB-723620) is a selective and orally active nonpeptide CRF1 receptor antagonist with an IC50 of 58.9 nM and a Ki of 4.0 nM for human CRF1 receptor. NBI-34041 has no inhibitory effect on the CRF2 receptor. NBI-34041 can be used for depression and anxiety disorders research.

• Product Name Alternative:

  SB-723620

• UNSPSC:

  12352005

• Target:

  CRFR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/nbi-34041.html

• Smiles:

  CC1=NC2=C3C(N(C(CCC)CCC)CCN3N=C2C4=CC=C(Cl)C=C4Cl)=C1

• Molecular Formula:

  C22H26Cl2N4

• Molecular Weight:

  417.37

• References & Citations:

  [1]Marcus Ising, et al. High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response. Neuropsychopharmacology. 2007 Sep;32 (9) :1941-9.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  CRFR1; CRFR2

• CAS Number:

  [268545-87-5]