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NBI-98782

CAT: 0804-HY-15793-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15793-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NBI-98782 is a high affinity and selectivity vesicular monoamine transporter 2 (VMAT2) inhibitor with a Ki of 3 nM. NBI-98782 has antipsychotic activity[1].
CAS Number
85081-18-1
Product Name Alternative
(+) -DTBZ; (+) -α-Dihydrotetrabenazine; (+) -α-DHTBZ
UNSPSC
12352005
Hazard Statement
H301, H336, H373
Target
Monoamine Transporter
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nbi-98782.html
Purity
98.56
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
COC(C=C1CCN2C[C@@H](CC(C)C)[C@@H]3O)=C(C=C1[C@]2(C3)[H])OC
Molecular Formula
C19H29NO3
Molecular Weight
319.44
Precautions
H301, H336, H373
References & Citations
[1]Huang M, et al. Effects of NBI-98782, a selective vesicular monoamine transporter 2 (VMAT2) inhibitor, on neurotransmitter efflux and phencyclidine-induced locomotor activity: Relevance to tardive dyskinesia and antipsychotic action. Pharmacol Biochem Behav. 2020 Mar;190:172872.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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