(±) -NBI-74330

CAT: 0804-HY-110099-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-110099-01Size:1 mg
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Description
(±) -NBI-74330 is a potent and selective CXCR3 antagonist. (±) -NBI-74330 not only reduces tactile and thermal hypersensitivity but also enhances the analgesic properties of morphine. (±) -NBI-74330 can reduce microglial cell activation, increase astroglial cell activation, and downregulate the expression of some CXCR3 ligands in a rat neuropathic pain model[1].
CAS Number
[473722-68-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/racemic-nbi-74330.html
Purity
99.12
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=C(N=C(C(C)N(CC3=CC=CN=C3)C(CC4=CC=C(C(C(F)(F)F)=C4)F)=O)N1C5=CC=C(C=C5)OCC)N=CC=C2
Molecular Formula
C32H27F4N5O3
Molecular Weight
605.58
Precautions
H302, H315, H319, H335
References & Citations
[1]Piotrowska A, et al. Pharmacological blockade of CXCR3 by (±) -NBI-74330 reduces neuropathic pain and enhances opioid effectiveness - Evidence from in vivo and in vitro studies. Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864 (10) :3418-3437.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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