(±) -NBI-74330

• Description :

  (±) -NBI-74330 is a potent and selective CXCR3 antagonist. (±) -NBI-74330 not only reduces tactile and thermal hypersensitivity but also enhances the analgesic properties of morphine. (±) -NBI-74330 can reduce microglial cell activation, increase astroglial cell activation, and downregulate the expression of some CXCR3 ligands in a rat neuropathic pain model[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  CXCR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/racemic-nbi-74330.html

• Purity :

  99.12

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1C2=C(N=C(C(C)N(CC3=CC=CN=C3)C(CC4=CC=C(C(C(F)(F)F)=C4)F)=O)N1C5=CC=C(C=C5)OCC)N=CC=C2

• Molecular Formula :

  C32H27F4N5O3

• Molecular Weight :

  605.58

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Piotrowska A, et al. Pharmacological blockade of CXCR3 by (±) -NBI-74330 reduces neuropathic pain and enhances opioid effectiveness - Evidence from in vivo and in vitro studies. Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864 (10) :3418-3437.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [473722-68-8]