NBI-6024

CAT: 0804-HY-106171Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-106171Size:1 Each
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Description
NBI-6024, an altered peptide ligand (APL), is an epitope recognized by inflammatory interferon-gamma-producing T helper lymphocytes in type 1 diabetic patients[1][2].
CAS Number
[239480-61-6]
UNSPSC
12352209
Target
Insulin Receptor
Type
Peptides
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/nbi-6024.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)C(C)C)N[C@H](C(NCC(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(O)=O)=O)CCC(O)=O)=O)CC(N)=O)=O)C)=O)CCC2)=O)[C@@H](C)O)=O)CC(C)C)=O)CO)=O)CC(O)=O)=O)CC(C)C)=O)C)=O)CCC1)=O)[C@H](CC)C)=O)C(C)C)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(C)C)=O)C)=O)C(C)C)=O)=O)=O)=O)CC(C)C
Molecular Formula
C106H180N28O34
Molecular Weight
2390.73
References & Citations
[1]D G Alleva et al. Immunomodulation in type 1 diabetes by NBI-6024, an altered peptide ligand of the insulin B epitope. Scand J Immunol. 2006 Jan;63 (1) :59-69. |[2]Alleva DG, et al. Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide. Diabetes. 2002 Jul;51 (7) :2126-34.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Phase 2

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