NBI-6024

• Description:

  NBI-6024, an altered peptide ligand (APL), is an epitope recognized by inflammatory interferon-gamma-producing T helper lymphocytes in type 1 diabetic patients[1][2].

• UNSPSC:

  12352209

• Target:

  Insulin Receptor

• Type:

  Peptides

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/nbi-6024.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@@H](N)C(C)C)N[C@H](C(NCC(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(O)=O)=O)CCC(O)=O)=O)CC(N)=O)=O)C)=O)CCC2)=O)[C@@H](C)O)=O)CC(C)C)=O)CO)=O)CC(O)=O)=O)CC(C)C)=O)C)=O)CCC1)=O)[C@H](CC)C)=O)C(C)C)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(C)C)=O)C)=O)C(C)C)=O)=O)=O)=O)CC(C)C

• Molecular Formula:

  C106H180N28O34

• Molecular Weight:

  2390.73

• References & Citations:

  [1]D G Alleva et al. Immunomodulation in type 1 diabetes by NBI-6024, an altered peptide ligand of the insulin B epitope. Scand J Immunol. 2006 Jan;63 (1) :59-69. |[2]Alleva DG, et al. Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide. Diabetes. 2002 Jul;51 (7) :2126-34.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  Phase 2

• CAS Number:

  [239480-61-6]