IL-17A antagonist 1

• UNSPSC Description:

  IL-17A antagonist 1 (compound 1) is an IL-17A antagonist, with a Kd of 0.66 μM and an IC50 of 1.14 μM[1].

• Target Antigen:

  Interleukin Related

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/IL-17A_antagonist_1.html

• Purity:

  99.74

• Solubility:

  DMSO : 41.67 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C(N(C)C)CC1(CC(NCCC2=CC=C(NC([C@H](CC3=CC=CC=C3F)NC(C4=CC=NN4C)=O)=O)C=C2)=O)CCCC1

• Molecular Weight:

  604.71

• References & Citations:

  [1]Liu S, et al. Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists. Sci Rep. 2016 Aug 16;6:30859.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  2205034-18-8