CGS 35601

CAT: 0804-HY-18211Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-18211Size:1 Each
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Description
CGS 35601 is the inhibitor for endothelin-converting enzyme-1 (ECE-1), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme (ACE), with IC50s of 55, 2, and 22 nM, respectively. CGS 35601 suppresses the big endothelin-1 (big ET-1) - and angiotensin I-induced pressor response, and enhances circulation of atrial natriuretic peptide (ANP), regulates the cardiovascular function in SD rats[1].
CAS Number
[849066-09-7]
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cgs-35601.html
Smiles
CC(C)C[C@H](S)C(NC1(CCCC1)C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(O)=O)=O)=O
Molecular Formula
C23H31N3O4S
Molecular Weight
445.58
References & Citations
[1]Trapani AJ, et al., CGS 35601 and its orally active prodrug CGS 37808 as triple inhibitors of endothelin-converting enzyme-1, neutral endopeptidase 24.11, and angiotensin-converting enzyme. J Cardiovasc Pharmacol. 2004 Nov;44 Suppl 1:S211-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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