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CGS 27023A

CAT: 0804-HY-18694Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-18694Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CGS 27023A is a non-peptidic and orally active MMP inhibitor with the Ki values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A prevents cartilage degradation in stromelysin-induced rabbit cartilage degradation model. CGS 27023A can be used for study of arthritis[1].
CAS Number
169799-04-6
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cgs-27023a.html
Solubility
10 mM in DMSO
Smiles
CC(C)[C@@H](N(S(=O)(C1=CC=C(OC)C=C1)=O)CC2=CC=CN=C2)C(NO)=O.[H]Cl
Molecular Formula
C18H24ClN3O5S
Molecular Weight
429.92
References & Citations
[1]MacPherson LJ, et al. Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits. J Med Chem. 1997;40 (16) :2525-2532.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-1; MMP-2; MMP-3; MMP-9

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