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FGFR-IN-16

CAT: 0804-HY-168286Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168286Size:1 Each
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Description
FGFR-IN-16 (compound 7N) is a potent inhibitor of FGFR1, FGFR2, and FGFR4, with the IC50s of 8 nM, 4 nM and 3.8 nM, respectively. FGFR-IN-16 plays an important role in cancer research1].
CAS Number
2170748-42-0
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr-in-16.html
Smiles
C=CC(NC1=CC(N2CCOCC2)=CC=C1NC3=NC=C(C=C(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C5=NC=CN56)C6=N3)=O
Molecular Formula
C30H27Cl2N7O4
Molecular Weight
620.49
References & Citations
[1]Jisook Kim, et al. Structure–activity relationship studies of Imidazo[1′,2′:1,6]pyrido[2,3-d]pyrimidine derivatives to develop selective FGFR inhibitors as anticancer agents for FGF19-overexpressed hepatocellular carcinoma. Eur J Med Chem. 2024 Nov 12:282:117047.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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