DB-0646

• Description:

  DB-0646, a PROTAC, is a multi-kinase degrader[1].

• UNSPSC:

  12352005

• Target:

  PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/db-0646.html

• Purity:

  98.0

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C (N1C2CCC (NC2=O) =O) C3=C (OCCCCCN4N=NC (CN5CCN (C6=NC=C (NC7=NC=C8C (N (C) C (N (C9=CC (NC (C%10=CC=CC (C (F) (F) F) =C%10) =O) =CC=C9C) C8) =O) =N7) C=C6) CC5) =C4) C=CC=C3C1=O

• Molecular Formula:

  C52H51F3N14O7

• Molecular Weight:

  1041.05

• References & Citations:

  [1]Katherine A Donovan, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183 (6) :1714-1731.e10.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2769753-59-3