DB-0646

• Description :

  DB-0646, a PROTAC, is a multi-kinase degrader[1].

• CAS Number :

  [2769753-59-3]

• UNSPSC :

  12352005

• Target :

  PROTACs

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/db-0646.html

• Purity :

  98.0

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(N1C2CCC(NC2=O)=O)C3=C(OCCCCCN4N=NC(CN5CCN(C6=NC=C(NC7=NC=C8C(N(C)C(N(C9=CC(NC(C%10=CC=CC(C(F)(F)F)=C%10)=O)=CC=C9C)C8)=O)=N7)C=C6)CC5)=C4)C=CC=C3C1=O

• Molecular Formula :

  C52H51F3N14O7

• Molecular Weight :

  1041.05

• References & Citations :

  [1]Katherine A Donovan, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183 (6) :1714-1731.e10.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported