NNC-0640

• Description :

  NNC-0640 is an effective negative allosteric modulator (NAM) of the human glucagon receptor (GCGR), with an IC50 value of 69.2 nM. NNC-0640 holds potential for research in the field of diabetes[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H228, H315, H319

• Target :

  GCGR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/nnc-0640.html

• Purity :

  98.43

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  O=C(NC1=NN=NN1)C2=CC=C(CN(C3=CC=C(C4CCCCC4)C=C3)C(NC5=CC=CC(S(=O)(C)=O)=C5)=O)C=C2

• Molecular Formula :

  C29H31N7O4S

• Molecular Weight :

  573.67

• Precautions :

  H228, H315, H319

• References & Citations :

  [1]Zhang H, et al. Structure of the full-length glucagon class B G-protein-coupled receptor. Nature. 2017 Jun 8;546 (7657) :259-264.|[2]Song G, et al. Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature. 2017 Jun 8;546 (7657) :312-315.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [307986-98-7]