NNC-0640

CAT: 0804-HY-124622-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-124622-01Size:5 mg
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Description
NNC-0640 is an effective negative allosteric modulator (NAM) of the human glucagon receptor (GCGR), with an IC50 value of 69.2 nM. NNC-0640 holds potential for research in the field of diabetes[1].
CAS Number
[307986-98-7]
UNSPSC
12352005
Hazard Statement
H228, H315, H319
Target
GCGR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/nnc-0640.html
Purity
98.43
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NC1=NN=NN1)C2=CC=C(CN(C3=CC=C(C4CCCCC4)C=C3)C(NC5=CC=CC(S(=O)(C)=O)=C5)=O)C=C2
Molecular Formula
C29H31N7O4S
Molecular Weight
573.67
Precautions
H228, H315, H319
References & Citations
[1]Zhang H, et al. Structure of the full-length glucagon class B G-protein-coupled receptor. Nature. 2017 Jun 8;546 (7657) :259-264.|[2]Song G, et al. Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature. 2017 Jun 8;546 (7657) :312-315.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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