L3MBTL3, GST-tag Recombinant

• Background:

  PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis.

• Description:

  Human lethal (3) malignant brain tumor-like protein 3 (L3MBTL3), GenBank Accession No. NM_032438, a.a. 229-547 with N-terminal GST-tag, MW = 63.6 kDa, expressed in anE. colicell expression system.

• UniProt:

  Q96JM7

• Tag:

  N-terminal GST-tag

• Applications:

  Useful for the study of Polycomb group (PcG) proteins, protein binding assays, screening inhibitors, and selectivity profiling.

• Purity:

  ≥ 90%

• Format:

  Aqueous buffer solution

• Shipping Conditions:

  -80°C

• Storage Conditions:

  ≥ 6 months at -80°C

• Calculated Molecular Weight:

  63.6 kDa

• Formulation:

  40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, 1.8 mM glutathione, 0.007% Tween-20, and 20% glycerol.