CBX2, GST-tag Recombinant

• Background:

  Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys119, rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression.

• Description:

  Human chromobox homolog 2 (CBX2), also known as SRXY5 and cell division cycle associated 6 (CDCA6), GenBank Accession No. NM_005189, a.a. 2-90, with N-terminal GST-tag, MW=37.3 kDa, expressed in anE. colicell expression system.

• UniProt:

  Q14781

• Tag:

  N-terminal GST-tag

• Applications:

  Useful for protein binding assays, screening inhibitors, and selectivity profiling.

• Purity:

  ≥ 79%

• Format:

  Aqueous buffer solution

• Shipping Conditions:

  -80°C

• Storage Conditions:

  ≥ 6 months at -80°C

• Calculated Molecular Weight:

  37.3 kDa

• Formulation:

  40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, 16 mM glutathione, 20% glycerol.