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HDAC6-IN-44

CAT: 0804-HY-162630Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162630Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC6-IN-44 (compound H10) is a selective HDAC6 inhibitor with an IC50 value of 8.97 nM. HDAC6-IN-44 can inhibit the idiopathic pulmonary fibrosis (IPF) phenotype and exhibits antifibrotic activity. Additionally, HDAC6-IN-44 reduces fibrogenesis in a bleomycin-induced pulmonary fibrosis mouse model and demonstrates good metabolic stability. HDAC6-IN-44 holds promise for research in the field of idiopathic pulmonary fibrosis[1].
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hdac6-in-44.html
Smiles
O=C(NO)C1=CC=C(CN2C([C@@](CCC3)([H])N3CC4=CC=CC=C42)=O)C=C1
Molecular Formula
C20H21N3O3
Molecular Weight
351.40
References & Citations
[1]Li Y, et al. Discovery of novel pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione (PBD) derivatives as selective HDAC6 inhibitors for the efficient treatment of idiopathic pulmonary fibrosis (IPF) in vitro and in vivo. Eur J Med Chem. 2024 Jun 17;275:116608.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC10; HDAC11; HDAC2; HDAC4; HDAC6; HDAC7

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