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Biotin-COG1410 (TFA)

CAT: 0804-HY-P2136F-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P2136F-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Biotin-COG1410 TFA is a biotin labled COG1410. COG1410 is an apolipoprotein E-derived peptide and an apoptosis inhibitor. COG1410 exerts neuroprotective and antiinflammatory effects in a murine model of traumatic brain injury (TBI). COG1410 can be used for the research of neurological disease[1][2].
UNSPSC
12352209
Target
Apolipoprotein; Apoptosis
Type
Peptides
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/biotin-cog1410-tfa.html
Purity
98.00
Solubility
10 mM in DMSO
Smiles
CC(C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C(C)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C(C)(NC([C@@H](NC([C@@H](NC(C)=O)C)=O)CO)=O)C)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCCCN)=O)CC(C)C)=O)C)=O)CCCCNC(CCCC[C@@H]1SC[C@]([H])(N2)[C@@]1(NC2=O)[H])=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)C(N)=O)C.OC(C(F)(F)F)=O.[x]
Molecular Formula
C74H135N23O16S.xC2HF3O2
References & Citations
[1]Laskowitz DT, et, al. COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury. J Neurotrauma. 2007 Jul;24 (7) :1093-107. |[2]Tukhovskaya EA, et, al. COG1410, a novel apolipoprotein-E mimetic, improves functional and morphological recovery in a rat model of focal brain ischemia. J Neurosci Res. 2009 Feb 15;87 (3) :677-82. |[3]Kuai L, et, al. Apolipoprotein E-Mimetic Peptide COG1410 Enhances Retinal Ganglion Cell Survival by Attenuating Inflammation and Apoptosis Following TONI. Front Neurosci. 2019 Sep 13;13:980.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported

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