TT-012

• Description:

  TT-012 is a specifical inhibitor of MITF (microphthalmia transcription factor) and destroys the MITF's dimer formation and DNA-binding ability. TT-012 inhibits the transcriptional activity of MITF in B16F10 melanoma cells. TT-012 inhibits the growth of high-MITF melanoma cells, and inhibits the tumor growth and metastasis with tolerable toxicity to liver and immune cells in animal models[1].

• UNSPSC:

  12352005

• Target:

  DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tt-012.html

• Purity:

  99.76

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(/C=C/C1=CC=CO1)NC2=CC=CC(NC(/C=C/C3=CC=CO3)=O)=N2

• Molecular Formula:

  C19H15N3O4

• Molecular Weight:

  349.34

• References & Citations:

  [1]Liu Z, et al. A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res. 2023 Jan;33 (1) :55-70.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1164471-33-3]