TT-012

CAT: 0804-HY-156483-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-156483-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
TT-012 is a specifical inhibitor of MITF (microphthalmia transcription factor) and destroys the MITF's dimer formation and DNA-binding ability. TT-012 inhibits the transcriptional activity of MITF in B16F10 melanoma cells. TT-012 inhibits the growth of high-MITF melanoma cells, and inhibits the tumor growth and metastasis with tolerable toxicity to liver and immune cells in animal models[1].
CAS Number
[1164471-33-3]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tt-012.html
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(/C=C/C1=CC=CO1)NC2=CC=CC(NC(/C=C/C3=CC=CO3)=O)=N2
Molecular Formula
C19H15N3O4
Molecular Weight
349.34
References & Citations
[1]Liu Z, et al. A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res. 2023 Jan;33 (1) :55-70.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-107084TT-62
HY-105172-01TT-232
HY-125016-01TT-10
HY-129658A-01TT-OAD2
HY-111203TT-301
HY-117517-01NG-012
HY-118315-01L-012
HY-105172ATT-232 (TFA)
HY-129658TT-OAD2 (free base)
HY-108537-01L 012 (sodium salt)

Alternative Products

CatalogName
C8532-5TT-012
ABC-TC484STT
256978TT 232
BA9127-10TT-10
T13218-01TT-OAD2
T29021-01TT-301
460704-01NG 012
MBS5823328NG-012

Popular Products