TT-10

• Description :

  TT-10 (TAZ-K) is an activator of YES-associated protein (YAP) -transcriptional enhancer factor domain (TEAD) activity. TT-10 can be used for the research of heart diseases accompanied by cardiomyocyte loss[1].

• Product Name Alternative :

  TAZ-K

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  YAP

• Type :

  Reference compound

• Related Pathways :

  Stem Cell/Wnt

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/tt-10.html

• Purity :

  99.95

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=C(N)N=C(NCC=C)S1)C2=CC=C(F)S2

• Molecular Formula :

  C11H10FN3OS2

• Molecular Weight :

  283.35

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Masamichi Ito, et al. Characterization of a small molecule that promotes cell cycle activation of human induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2019 Mar;128:90-95.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [2230640-94-3]