TT-10

TT-10

• Description:

  TT-10 (TAZ-K) is an activator of YES-associated protein (YAP) -transcriptional enhancer factor domain (TEAD) activity. TT-10 can be used for the research of heart diseases accompanied by cardiomyocyte loss[1].

• Product Name Alternative:

  TAZ-K

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  YAP

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tt-10.html

• Purity:

  99.95

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=C(N)N=C(NCC=C)S1)C2=CC=C(F)S2

• Molecular Formula:

  C11H10FN3OS2

• Molecular Weight:

  283.35

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Masamichi Ito, et al. Characterization of a small molecule that promotes cell cycle activation of human induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2019 Mar;128:90-95.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  [2230640-94-3]