L-012

• UNSPSC Description:

  L-012 is a chemiluminescent probe that reacts with various types of ROS produced by activated neutrophils in human blood, oral cavity, and rat peritoneum and produces strong chemiluminescence (CHL). L-012 produces CHL primarily by reacting with hydroxyl radicals and hypochlorite. L-012 can be used to study ROS generation in complex biological systems and the role of ROS in the pathogenesis of various diseases[1].

• Target Antigen:

  Fluorescent Dye

• Type:

  Reference compound

• Related Pathways:

  Others

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/l-012.html

• Smiles:

  O=C(C1=C2C(Cl)=NC(C3=CC=CC=C3)=C1N)NNC2=O

• Molecular Weight:

  288.69

• References & Citations:

  [1]Zielonka J, et al. On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: a reevaluation. Free Radic Biol Med. 2013;65:1310-1314.|[2]Kielland A, et al. In vivo imaging of reactive oxygen and nitrogen species in inflammation using the luminescent probe L-012. Free Radic Biol Med. 2009;47(6):760-766.|[3]Imada I, et al. Analysis of reactive oxygen species generated by neutrophils using a chemiluminescence probe L-012[J]. Analytical biochemistry, 1999, 271(1): 53-58.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  143323-55-1