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Bivalirudin (TFA)

CAT: 0804-HY-15664-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15664-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bivalirudin TFA, a hirudin analog and anticoagulant, is a direct thrombin inhibitor. Bivalirudin TFA inhibits thrombin-mediated fibrinogen cleavage, coagulation factor activation, and platelet activation by reversibly binding to thrombin. In addition, Bivalirudin TFA also has certain effects of anti-virus, anti-inflammation, and vascular endothelial barrier function protection. Bivalirudin TFA can be used for the research of thrombotic diseases and others[1][2][3][4].
CAS Number
1191386-55-6
UNSPSC
12352209
Target
Interleukin Related; RSV; Thrombin
Type
Peptides
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Bivalirudin-Trifluoroacetate.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL
Smiles
C(C(O)=O)(F)(F)F.C([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC(CNC([C@@H](NC(CNC(CNC(CNC(CNC(=O)[C@H]2N(C([C@@H](NC(=O)[C@H]3N(C([C@@H](CC4=CC=CC=C4)N)=O)CCC3)CCCNC(=N)N)=O)CCC2)=O)=O)=O)=O)CC(N)=O)=O)=O)CC(O)=O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)[C@H](CC)C)(=O)N5[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC6=CC=C(O)C=C6)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCC5
Molecular Formula
C98H138N24O33.C2HF3O2
Molecular Weight
2294.34
References & Citations
[1]Ye H, et al. Bivalirudin Attenuates Thrombin-Induced Endothelial Hyperpermeability via S1P/S1PR2 Category: Original Articles. Front Pharmacol. 2021 Aug 3;12:721200.|[2]Zhuang S, et al. Bivalirudin exerts antiviral activity against respiratory syncytial virus-induced lung infections in neonatal mice. Acta Pharm. 2022 Apr 13;72 (3) :415-425.|[3]Warkentin TE, et al. Bivalirudin: a review. Expert Opin Pharmacother. 2005 Jul;6 (8) :1349-71.|[4]André P, et al. Anticoagulants (thrombin inhibitors) and aspirin synergize with P2Y12 receptor antagonism in thrombosis.Circulation. 2003 Nov 25;108 (21) :2697-703.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
Launched
Isoform
IL-5; IL-6
Citation 01
Allergy. 2022 Jul;77 (7) :2104-2120.|Antiviral Res. 2023 Jun:214:105606.|Compos B Eng. 1 April 2022, 109702.|Elife. 2022 Mar 23:11:e77444.|Int J Auto Tech-Jpn. 2020 Jan.|J Am Soc Mass Spectrom. 2020 Jul 5.|J Clin Pathol. 2019 Dec;72 (12) :817-824.|bioRxiv. 2025 Sep 26.|Compos B Eng. 2024 Aug 15.

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