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PAX-6 Antibody

CAT: 0800-V2772-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V2772-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P26367
Host
Mouse
Reactivity
Human
Immunogen
A recombinant fragment (N-terminus; aa 1-300) was used as the immunogen for the PAX-6 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM612
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the PAX-6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PAX-6 antibody is available for research use only.
Storage Conditions
Store the PAX-6 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Nuclear
Image Legend
IHC: Formalin-fixed, paraffin-embedded human gastric carcinoma stained with PAX-6 antibody (SPM612) .

UniProtKB · P26367

Paired box protein Pax-6

PAX6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P26367
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PAX6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q6N006, Q99413
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

Developmental proteinDNA-bindingRepressor

Biological process

DifferentiationTranscriptionTranscription regulation

Disease

Disease variantPeters anomaly

Domain

HomeoboxPaired box

Cellular component

Nucleus

PTM

Ubl conjugation

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