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PAX-7 Antibody

CAT: 0800-V2774IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V2774IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The Pax gene family of nuclear transcription factors is comprised of nine members that function during embryogenesis to regulate the temporal and position-dependent differentiation of cells. In addition, the family is involved in a variety of signal transduction pathways in the adult organism. Mutations in the Pax family of proteins have been linked to disease and cancer in humans. Pax-7 is a protein specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization reveals that Pax-7 is also expressed in satellite cells residing in adult muscle. A chromosomal aberration in the gene encoding Pax-7 causes rhabdomyosarcoma 2 (RMS2) (also called alveolar rhabdomyosarcoma) .
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
P23759
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human PAX7 protein corresponding to amino acids 301-505 was used as the immunogen for this PAX-7 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM613
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the PAX-7 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PAX-7 antibody is available for research use only.
Storage Conditions
Store the PAX-7 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Nuclear
Image Legend
IHC testing of FFPE human Rhabdomyosarcoma with PAX-7 antibody (clone SPM613) .

UniProtKB · P23759

Paired box protein Pax-7

PAX7_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P23759
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PAX7
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
E9PFV9, Q0VA99, Q2PJS5
Protein keywords

PTM

Acetylation

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Molecular function

Developmental proteinDNA-binding

Disease

Disease variantProto-oncogene

Domain

HomeoboxPaired box

Biological process

MyogenesisTranscriptionTranscription regulation

Cellular component

Nucleus

Technical term

Proteomics identificationReference proteome

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