PAX-7 Antibody

CAT: 0800-V2774-100UGSize: 100 µgDry Ice: NoHazardous: No

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CAT#:0800-V2774-100UGSize:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

The Pax gene family of nuclear transcription factors is comprised of nine members that function during embryogenesis to regulate the temporal and position-dependent differentiation of cells. In addition, the family is involved in a variety of signal transduction pathways in the adult organism. Mutations in the Pax family of proteins have been linked to disease and cancer in humans. Pax-7 is a protein specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization reveals that Pax-7 is also expressed in satellite cells residing in adult muscle. A chromosomal aberration in the gene encoding Pax-7 causes rhabdomyosarcoma 2 (RMS2) (also called alveolar rhabdomyosarcoma) .

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT

UniProt

P23759

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human PAX7 protein corresponding to amino acids 301-505 was used as the immunogen for this PAX-7 antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

SPM613

Applications

IHC-P

Purity

Protein G affinity chromatography

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Reconstitution

Store the PAX-7 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This PAX-7 antibody is available for research use only.

Storage Conditions

Store the PAX-7 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide

Location

Nuclear

Image Legend

IHC testing of FFPE human Rhabdomyosarcoma with PAX-7 antibody (clone SPM613) .

UniProtKB · P23759

Paired box protein Pax-7

PAX7_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P23759
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PAX7
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: E9PFV9, Q0VA99, Q2PJS5

Protein keywords

PTM

Acetylation

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Molecular function

Developmental proteinDNA-binding

Disease

Disease variantProto-oncogene

Domain

HomeoboxPaired box

Biological process

MyogenesisTranscriptionTranscription regulation

Cellular component

Nucleus

Technical term

Proteomics identificationReference proteome

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Alternative Products

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GTR18572645	PAX-7 Antibody
abx339741-01	Paired Box Protein Pax-7 (PAX7) Antibody
A00845-1	Anti-Paired box protein Pax-7 PAX7 Antibody
MBS8517703-01	Pax-9 Antibody
MBS8517003-01	Pax-6 Antibody
MBS8510732-01	Pax-5 Antibody
MBS9508984-01	Pax-2 Antibody
abx130294-01	Paxillin (Pax) Antibody
N0508-01	Pax-8 Antibody
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