Products for Research Use Only
RegisterLogin

PAX-8 Antibody

CAT: 0800-V3412SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-V3412SAF-100UGSize:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PAX-8 is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q06710
Host
Mouse
Reactivity
Human
Immunogen
A human recombinant fragment (aa 60-261) was used as the immunogen for the PAX-8 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
PAX8/1491
Applications
WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the PAX-8 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PAX-8 antibody is available for research use only.
Storage Conditions
Store the PAX-8 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the PAX-8 antibody should be determined by the researcher.
Location
Nuclear, cytoplasmic
Image Legend
Western blot testing of 1) human partial recombinant protein and 2) human Raji cell lysate with PAX-8 antibody (clone PAX8/1491) . Predicted molecular weight of isoforms 1-5: 31, 35, 42, 43 and 48 kDa, respectively. PAX-8 can also be observed at ~62 kDa.

UniProtKB · Q06710

Paired box protein Pax-8

PAX8_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q06710
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PAX8
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q09155, Q16337, Q16338, Q16339, Q4ZG35, Q96J49
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Congenital hypothyroidismDisease variant

Molecular function

Developmental proteinDNA-binding

Biological process

DifferentiationTranscriptionTranscription regulation

Cellular component

Nucleus

Domain

Paired box

PTM

Phosphoprotein

Related Products

CatalogName
V4911-20UGPAX8 Antibody / Paired box protein Pax-8
V4911-100UGPAX8 Antibody / Paired box protein Pax-8
V4911SAF-100UGPAX8 Antibody / Paired box protein Pax-8
V2774SAF-100UGPAX-7 Antibody
V2774-100UGPAX-7 Antibody
F40690-0.4MLPAX-7 Antibody
F49968-0.4MLPAX-6 Antibody
V2772-100UGPAX-6 Antibody
V2772-20UGPAX-6 Antibody
V2772SAF-100UGPAX-6 Antibody

Alternative Products

CatalogName
MBS9436860-01PAX-8 Antibody
MBS2580046-01Pax-8 Monoclonal Antibody
34066Anti-PAX-8 Antibody
N2002-01PAX-8 Antibody (2B11)
ABP52155-01Pax-8 Polyclonal Antibody
GTR17857992Polyclonal PAX-8 Antibody
STJ180300Anti-PAX-8 antibody
403419-01Pax-8
CR381-0.1mlPAX 8

Popular Products