NK-252

• Description :

  NK-252 is a potential Nrf2 activator, which exhibits a great Nrf2-activating potential.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Keap1-Nrf2; Quinone Reductase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/NK-252.html

• Purity :

  99.60

• Solubility :

  DMSO : ≥ 29 mg/mL

• Smiles :

  O=C(NCC1=NC=CC=C1)NC2=NN=C(C3=CC=CO3)O2

• Molecular Formula :

  C13H11N5O3

• Molecular Weight :

  285.26

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Shimozono R et al. Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol Pharmacol. 2013 Jul, 84 (1) :62-70.|[2]Kiue A, et al. Enhancement of antitumour activity of etoposide by dihydropyridines on drug-sensitive and drug-resistant leukaemia in mice. Br J Cancer. 1991 Aug;64 (2) :221-6.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1414963-82-8]