NK-611

• Description :

  NK-611 (VP 19) is an epipodophyllotoxin derivative. NK-611 induces DNA double-strand breaks by inhibiting topoisomerase II (IC50 = 56 μM) . NK-611 does not inhibit microtubule polymerization, thus avoiding the side effects of the parent compound, Podofilox (HY-15552) . NK-611 exhibits broad-spectrum antitumor activity and demonstrates potent efficacy in in vivo models of leukemia. NK-611 can be used in cancer research[1][2].

• Product Name Alternative :

  VP 19

• UNSPSC :

  12352005

• Target :

  DNA/RNA Synthesis; Topoisomerase

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=C1[C@]2([H])[C@H](C3=CC(OC)=C(O)C(OC)=C3)C4=CC(OCO5)=C5C=C4[C@@H](O[C@@]6([H])[C@@H]([C@H]([C@@]7([H])[C@](CO[C@@H](C)O7)([H])O6)O)N(C)C)[C@@]2([H])CO1

• Molecular Formula :

  C31H37NO12

• Molecular Weight :

  615.62

• References & Citations :

  [1]Daley L, et al. Synthesis and antitumor activity of new glycosides of epipodophyllotoxin, analogues of etoposide, and NK 611. J Med Chem. 1998 Nov 5;41 (23) :4475-85. |[2]Hanauske AR, et al. Activity of NK 611, a new epipodophyllotoxin derivative, against colony forming units from freshly explanted human tumours in vitro. Eur J Cancer. 1995 Sep;31A (10) :1677-81.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Topo II

• CAS Number :

  [105655-99-0]