NP-252

• UNSPSC Description:

  NP-252 is a calcium channel antagonist with an 20% effective dose (ED20) of 2.55 mg/kg in spontaneously hypertensive rats[1].

• Target Antigen:

  Calcium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/np-252.html

• Smiles:

  O=C(C1=C(C)NC(C)=C(C1C2=C([N+]([O-])=O)C=CC=C2)C(NC3CC3)=O)OCCCCCCCC

• Molecular Weight:

  469.57

• References & Citations:

  [1]Hojo M, et al. Acute antihypertensive effects of the new generation calcium antagonist 3-pyridine carboxylic acid 5-[(cyclopropylamino)-carbonyl]-1,4-dihydro-2,6-dimethyl-4-(2-nitrophen yl) octyl ester on conscious spontaneously hypertensive rats and renal hypertensive rats. Arzneimittelforschung. 1993 Aug;43(8):847-51.|[2]Hojo M, et al. Acute antihypertensive effects of the new generation calcium antagonist 3-pyridine carboxylic acid 5-[(cyclopropylamino)-carbonyl]-1,4-dihydro-2,6-dimethyl-4-(2-nitrophen yl) octyl ester on conscious spontaneously hypertensive rats and renal hypertensive rats. Arzneimittelforschung. 1993 Aug;43(8):847-51.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 1

• CAS Number:

  132031-81-3