NP-252

CAT: 0804-HY-19053Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-19053Size:1 Each
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Description
NP-252 is a calcium channel antagonist with an 20% effective dose (ED20) of 2.55 mg/kg in spontaneously hypertensive rats[1].
CAS Number
[132031-81-3]
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/np-252.html
Smiles
O=C(C1=C(C)NC(C)=C(C1C2=C([N+]([O-])=O)C=CC=C2)C(NC3CC3)=O)OCCCCCCCC
Molecular Formula
C26H35N3O5
Molecular Weight
469.57
References & Citations
[1]Hojo M, et al. Acute antihypertensive effects of the new generation calcium antagonist 3-pyridine carboxylic acid 5-[ (cyclopropylamino) -carbonyl]-1,4-dihydro-2,6-dimethyl-4- (2-nitrophen yl) octyl ester on conscious spontaneously hypertensive rats and renal hypertensive rats. Arzneimittelforschung. 1993 Aug;43 (8) :847-51.|[2]Hojo M, et al. Acute antihypertensive effects of the new generation calcium antagonist 3-pyridine carboxylic acid 5-[ (cyclopropylamino) -carbonyl]-1,4-dihydro-2,6-dimethyl-4- (2-nitrophen yl) octyl ester on conscious spontaneously hypertensive rats and renal hypertensive rats. Arzneimittelforschung. 1993 Aug;43 (8) :847-51.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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