NP-252

• Description :

  NP-252 is a calcium channel antagonist with an 20% effective dose (ED20) of 2.55 mg/kg in spontaneously hypertensive rats[1].

• UNSPSC :

  12352005

• Target :

  Calcium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/np-252.html

• Smiles :

  O=C(C1=C(C)NC(C)=C(C1C2=C([N+]([O-])=O)C=CC=C2)C(NC3CC3)=O)OCCCCCCCC

• Molecular Formula :

  C26H35N3O5

• Molecular Weight :

  469.57

• References & Citations :

  [1]Hojo M, et al. Acute antihypertensive effects of the new generation calcium antagonist 3-pyridine carboxylic acid 5-[ (cyclopropylamino) -carbonyl]-1,4-dihydro-2,6-dimethyl-4- (2-nitrophen yl) octyl ester on conscious spontaneously hypertensive rats and renal hypertensive rats. Arzneimittelforschung. 1993 Aug;43 (8) :847-51.|[2]Hojo M, et al. Acute antihypertensive effects of the new generation calcium antagonist 3-pyridine carboxylic acid 5-[ (cyclopropylamino) -carbonyl]-1,4-dihydro-2,6-dimethyl-4- (2-nitrophen yl) octyl ester on conscious spontaneously hypertensive rats and renal hypertensive rats. Arzneimittelforschung. 1993 Aug;43 (8) :847-51.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [132031-81-3]