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MMP10 Antibody

CAT: 0800-R32949Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32949Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Stromelysin-2, also known as Matrix metalloproteinase-10 (MMP-10) or Transin-2, is an enzyme that in humans is encoded by the MMP10 gene. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
CAS Number
9007-83-4
Specifications
Western Blot: 0.5-1 µg/mL, IHC (FFPE) : 1-2 µg/mL, IF/ICC (FFPE) : 1-2 µg/mL, Direct ELISA (human recombinant protein) : 0.1-0.5 µg/mL (BSA-free format available)
UniProt
P09238
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A recombinant human protein corresponding to amino acids Y239-C476 was used as the immunogen for the MMP10 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF/ICC, Direct ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the MMP10 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MMP10 antibody is available for research use only.
Storage Conditions
After reconstitution, the MMP10 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the MMP10 antibody should be determined by the researcher.
Location
Secreted
Image Legend
IHC testing of FFPE human breast cancer tissue with MMP10 antibody at 1ug/ml. Required HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to testing.

UniProtKB · P09238

Stromelysin-2

MMP10_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P09238
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MMP10
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
SL-2
EC number
3.4.24.22
Processing
Precursor
Secondary accessions
B2R9X9, Q53HH9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

CalciumMetal-bindingZinc

Biological process

Collagen degradation

PTM

Disulfide bondZymogen

Cellular component

Extracellular matrixSecreted

Molecular function

HydrolaseMetalloproteaseProtease

Domain

RepeatSignal

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