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HNF1B Antibody

CAT: 0800-R31391Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31391Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Hepatocyte nuclear factor 1 homeobox B, also known as Transcription factor 2 (TCF2), is a human gene. It is a member of the homeodomain-containing superfamily of transcription factors. The HNF1B protein is believed to form heterodimers with another liver-specific member of this transcription factor family, TCF1. It functions as both a classic transcriptional activator and as a bookmarking factor that marks target genes for rapid transcriptional reactivation after mitosis. HNF1B also can regulate renal tubulogenesis by controlling expression of SOC3. A mutation of the protein that disrupts normal function has been identified as the cause of MODY5 (Maturity-Onset of Diabetes, Type 5) .
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P35680
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the C-terminus of human Hepatocyte nuclear factor 1 homeobox B (HMAQQPFMAAVTQLQN) was used as the immunogen for this HNF1B antibody (100% homologous in human, mouse and rat) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the HNF1B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This HNF1B antibody is available for research use only.
Storage Conditions
After reconstitution, the HNF1B antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the HNF1B antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of HNF1B antibody and mouse liver lysate. Predicted molecular weight ~61 kDa.
Product Datasheet
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