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MMP12 Antibody

CAT: 0800-R31265Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31265Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Matrix metalloproteinase-12, also known as MME or ME, is an enzyme that in humans is encoded by the MMP12 gene. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.2. It is though that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. This gene may involved in tissue injury and remodeling.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P39900
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the C-terminus of human Matrix metalloproteinase-12 (KIDAVFYSKNKYYYFFQ) was used as the immunogen for this MMP12 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the MMP12 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MMP12 antibody is available for research use only.
Storage Conditions
After reconstitution, the MMP12 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the MMP12 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of MMP12 antibody and Lane 1: human SMMC-7721; 2: mouse HEPA; 3: (h) HeLa; 4: (h) K562; 5: (h) MCF-7 cell lysate. Predicted molecular weight: ~55 kDa (pro form), ~45 kDa and ~22 kDa (active forms) .
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