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ABCG1 Antibody

CAT: 0800-R30967Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30967Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ABCG1 (ATP-binding cassette, subfamily G, member 1) also known as ABC8, is a protein that in humans is encoded by the ABCG1 gene. ABCG1 is a regulator of macrophage cholesterol and phospholipid transport. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. The gene is mapped on 21q22.3. This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. ABCG1 is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. Inhibition of ABCG1 protein expression using an antisense strategy resulted in reduced HDL3-dependent efflux of cholesterol and choline-phospholipids. In macrophages, silencing of GPS2 by RNA interference reducedABCG1expression and diminished ABCG1-mediated cholesterol efflux.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P45844
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the C-terminus of human ABCG1 (ETCHFQKSEAILRELDVENAK) was used as the immunogen for this ABCG1 antibody (100% homologous in human, mouse and rat) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the ABCG1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This ABCG1 antibody is available for research use only.
Storage Conditions
After reconstitution, the ABCG1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the ABCG1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic
Image Legend
Western blot testing of ABCG1 antibody and Lane 1: U87; 2: SMMC-7721; 3: HeLa; 4: COLO320; 5: MCF-7 cell lysate. Predicted molecular weight: 75~90KD
Product Datasheet
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