ABCG5 Antibody

CAT: 0800-R30970Size: 100 µgDry Ice: NoHazardous: No
CAT#:0800-R30970Size:100 µg
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Description
ATP-binding cassette, subfamily G, member 5. also known as Sterolin 1, is a protein that in humans is encoded by the ABCG5 gene. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. This protein is a member of the White subfamily. It functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. The gene contains 13 exons and spans about 28 kb and is mapped on 2p21. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. Small(2003 )reviewed the role of ABC transporters in secretion of cholesterol from liver into bile, particularly the role of ABCG5/ABCG8. The ABCG5and ABCG8 genes are an example of closely neighboring genes in a head-to-head orientation that, when mutated, cause the same phenotype.
CAS Number
9007-83-4
UniProt
Q9H222
Host
Rabbit
Immunogen
An amino acid sequence from the N-terminus of human ABCG5 (NGRALRREQFQDCFSY) was used as the immunogen for this ABCG5 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS
Format
Antigen affinity purified
Buffer
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Reconstitution
After reconstitution, the ABCG5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This ABCG5 antibody is available for research use only.
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