ABCE1 Antibody

CAT: 0800-R32488Size: 100 µgDry Ice: NoHazardous: No
CAT#:0800-R32488Size:100 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ATP binding cassette E1 (ABCE1, also called RNase L inhibitor) is an ATPase found in humans involved in viral assembly. It is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L, and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumorcell proliferation and antiapoptosis.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunofluorescence: 5 µg/mL, Immunoprecipitation: 2ug antibody/500ug lysate, Flow cytometry: 1-3ug/million cells
UniProt
P61221
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids K419-D599 from the human protein were used as the immunogen for the ABCE1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IF, IP, FACS
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the ABCE1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This ABCE1 antibody is available for research use only.
Storage Conditions
After reconstitution, the ABCE1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Differences in protocols and secondary/substrate sensitivity may require the ABCE1 antibody to be titrated for optimal performance.
Location
Cytoplasmic
Image Legend
Immunofluorescent staining of FFPE human HeLa cells with ABCE1 antibody (green) and DAPI nuclear stain (blue) . HIER: steam section in pH6 citrate buffer for 20 min.

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