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Caspase-2 Antibody

CAT: 0800-R30278Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30278Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Caspase-2/CASP2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. Activation of Caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. Increased PIDD expression resulted in spontaneous activation of Caspase-2 and sensitization to apoptosis by genotoxic stimuli. CASP2 acts both as a positive and negative cell death effector, depending upon cell lineage and stage of development.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P42575
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 417-439 (REGYAPGTEFHRCKEMSEYCSTL) were used as the immunogen for this Caspase-2 antibody (100% homologous in human, mouse and rat) . This sequence is from the small subunit.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the Caspase-2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Caspase-2 antibody is available for research use only.
Storage Conditions
After reconstitution, the Caspase-2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting points. Titration of the Caspase-2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of Caspase-2 antibody and Lane 1: human CCRF-CEM; 2: human SMMC-7721 cell lysate. Predicted molecular weight: ~47 kDa (full), ~31 kDa (large+small subunit), ~11 kDa (small subunit) .

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