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Caspase-12 Antibody

CAT: 0800-F41865-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F41865-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
CAS Number
9007-83-4
UniProt
Q6UXS9
Host
Rabbit
Immunogen
A portion of amino acids 165-193 from the human protein was used as the immunogen for this Caspase-12 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, FACS, IF, ELISA
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Caspase-12 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Caspase-12 antibody is available for research use only.

UniProtKB · Q6UXS9

Inactive caspase-12

CASPC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q6UXS9
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CASP12
Protein existence
2: Evidence at transcript level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CASP-12
EC number
—
Processing
—
Secondary accessions
D6RBN7
Protein keywords

Coding sequence diversity

Alternative splicing

PTM

Phosphoprotein

Technical term

Reference proteome
Product Datasheet
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