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PKC alpha Antibody / PRKCA

CAT: 0800-F54980-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F54980-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PRKCA is a calcium-activated, phospholipid-dependent, serine-and threonine-specific enzyme. It may play a role in cell motility by phosphorylating CSPG4. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
CAS Number
9007-83-4
Specifications
Immunofluorescence: 1:25, Flow cytometry: 1:25 (1x10e6 cells), Immunohistochemistry (FFPE) : 1:25, Western blot: 1:500-1:2000
UniProt
P17252
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 75-103 from the human protein was used as the immunogen for the PKC alpha antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IF, FACS, IHC-P, WB
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the PKC alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PKC alpha antibody is available for research use only.
Storage Conditions
Aliquot the PKC alpha antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the PKC alpha antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic, nuclear
Image Legend
IHC testing of FFPE human lung carcinoma tissue with PKC alpha antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.

UniProtKB · P17252

Protein kinase C alpha type

KPCA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P17252
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PRKCA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PKC-A, PKC-alpha
EC number
2.7.11.13
Processing
—
Secondary accessions
B5BU22, Q15137, Q32M72, Q96RE4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Biological process

AngiogenesisApoptosisCell adhesion

Ligand

ATP-bindingCalciumMetal-bindingNucleotide-bindingZinc

Cellular component

Cell membraneCytoplasmMembraneMitochondrionNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

Disease

Proto-oncogene

Domain

RepeatZinc-finger

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