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PRKCA Antibody / PKC Alpha

CAT: 0800-RQ8049Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ8049Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Protein kinase C (PKC) is the major phorbol ester receptor. Activation of PKC by calcium ions and the second messenger diacylglycerol is thought to play a central role in the induction of cellular responses to a variety of ligand-receptor systems and in the regulation of cellular responsiveness to external stimuli. Three of these, termed alpha, beta and gamma, are highly homologous. PRKCA1 is mapped to 17q22-q23.2. PRKCA1 regulates cardiac contractility and propensity toward heart failure.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P17252
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
E. coli-derived recombinant human protein (amino acids Q142-V672) was used as the immunogen for the PRKCA antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the PRKCA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This PRKCA antibody is available for research use only.
Storage Conditions
After reconstitution, the PRKCA antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the PRKCA antibody should be determined by the researcher.
Image Legend
Flow cytometry testing of fixed and permeabilized human SiHa cells with PRKCA antibody at 1ug/million cells (blocked with goat sera) ; Red=cells alone, Green=isotype control, Blue= PRKCA antibody.

UniProtKB · P17252

Protein kinase C alpha type

KPCA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P17252
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PRKCA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PKC-A, PKC-alpha
EC number
2.7.11.13
Processing
—
Secondary accessions
B5BU22, Q15137, Q32M72, Q96RE4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Biological process

AngiogenesisApoptosisCell adhesion

Ligand

ATP-bindingCalciumMetal-bindingNucleotide-bindingZinc

Cellular component

Cell membraneCytoplasmMembraneMitochondrionNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

Disease

Proto-oncogene

Domain

RepeatZinc-finger

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