SLC5A8 Antibody

Solute carrier family 5 member 8 acts as an electrogenic sodium (Na (+) ) and chloride (Cl-) -dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na (+) :substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na (+) gradient and hence contribute to the maintenance of the energy status and function of neurons.

9007-83-4

Western blot: 1:500-1000

Q8N695

Human

A portion of amino acids 579-609 from the human protein was used as the immunogen for the SLC5A8 antibody.

WB

Antigen affinity

Antigen affinity purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the SLC5A8 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This SLC5A8 antibody is available for research use only.

Aliquot the SLC5A8 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

In 1X PBS, pH 7.4, with 0.09% sodium azide

Titration of the SLC5A8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.