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SLC1A1 Antibody / EAAT3

CAT: 0800-RQ5837Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ5837Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Solute carrier family 1 member 1, also called SLC1A1, is a protein that in humans is encoded by the SLC1A1 gene. By Southern analysis of a panel of human/rodent somatic cell hybrids and by fluorescence in situ hybridization (FISH), this gene is mapped to 9p24.2. This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are though to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P43005
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant human protein (amino acids Q160-F524) was used as the immunogen for the SLC1A1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, Direct ELISA
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the SLC1A1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This SLC1A1 antibody is available for research use only.
Storage Conditions
After reconstitution, the SLC1A1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the SLC1A1 antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) rat kidney and 2) mouse kidney lysate with SLC1A1 antibody. Expected molecular weight: 57-70 kDa.

UniProtKB · P43005

Excitatory amino acid transporter 3

EAA3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P43005
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SLC1A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
O75587, Q5VZ24, Q8N199, Q9UEW2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Amino-acid transportSymportTransport

Cellular component

Cell membraneEndosomeMembraneSynapseSynaptosome

Ligand

ChlorideMetal-bindingPotassiumSodium

Disease

Disease variantSchizophrenia

PTM

GlycoproteinPhosphoprotein

Domain

TransmembraneTransmembrane helix
Product Datasheet
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