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EAAT3 Antibody / SLC1A1

CAT: 0800-R31284Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31284Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Excitatory amino acid transporter 3 is a protein that in humans is encoded by the SLC1A1 gene. By Southern analysis of a panel of human/rodent somatic cell hybrids and by fluorescence in situ hybridization (FISH), this gene is mapped to 9p24.2. This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. EAAT3 also transports aspartate, and mutations in this gene are though to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P43005
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the N-terminus of human Excitatory amino acid transporter 3 (EWKRFLKNNWVLLSTVAA) was used as the immunogen for this EAAT3 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the EAAT3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This EAAT3 antibody is available for research use only.
Storage Conditions
After reconstitution, the EAAT3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the EAAT3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of EAAT3 antibody and human placenta tissue lysate. Expected molecular weight: 57-70 kDa.

UniProtKB · P43005

Excitatory amino acid transporter 3

EAA3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P43005
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SLC1A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
O75587, Q5VZ24, Q8N199, Q9UEW2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Amino-acid transportSymportTransport

Cellular component

Cell membraneEndosomeMembraneSynapseSynaptosome

Ligand

ChlorideMetal-bindingPotassiumSodium

Disease

Disease variantSchizophrenia

PTM

GlycoproteinPhosphoprotein

Domain

TransmembraneTransmembrane helix

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