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HNF4A Antibody

CAT: 0800-F48197-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F48197-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HNF4A is a nuclear transcription factor which binds DNA as a homodimer. This protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This protein may play a role in development of the liver, kidney, and intestines. Mutations in this protein have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P41235
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 118-146 from the human protein was used as the immunogen for this HNF4A antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the HNF4A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This HNF4A antibody is available for research use only.
Storage Conditions
Aliquot the HNF4A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the HNF4A antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Mouse, Rat, Xenopus
Image Legend
Western blot analysis of HNF4A antibody and NCI-H460 lysate. Predicted molecular weight ~50 kDa.

UniProtKB · P41235

Hepatocyte nuclear factor 4-alpha

HNF4A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P41235
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HNF4A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
HNF-4-alpha
EC number
—
Processing
—
Secondary accessions
A5JW41, B2RPP8, O00659, O00723, Q14540, Q5QPB8, Q6B4V5, Q6B4V6, Q6B4V7, Q92653, Q92654, Q92655, Q99864, Q9NQH0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-bindingReceptorRepressor

Coding sequence diversity

Alternative promoter usageAlternative splicing

Biological process

Biological rhythmsTranscriptionTranscription regulation

Disease

Diabetes mellitusDisease variant

Ligand

Metal-bindingZinc

Cellular component

Nucleus

Domain

Zinc-finger

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