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VEGFR2-IN-2

CAT: 0804-HY-147133-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-147133-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VEGFR2-IN-2 (compound 6e) is a potent and selective VEGFR2 inhibitor with an IC50 of 19.32 nM. VEGFR2-IN-2 can be used for researching
CAS Number
737818-56-3
UNSPSC
12352005
Hazard Statement
H315, H319
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vegfr2-in-2.html
Concentration
10mM
Purity
99.26
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
BrC1=CC=C(COC2=C3C=CC=CC3=NC=N2)C=C1
Molecular Formula
C15H11BrN2O
Molecular Weight
315.16
Precautions
H315, H319
References & Citations
[1]Sun J, et al. Design, synthesis, biological evaluation, and molecular modeling study of 4-alkoxyquinazoline derivatives as potential VEGFR2 kinase inhibitors. Org Biomol Chem. 2013 Nov 28;11 (44) :7676-86.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1

Chemical Information

4-[(4-Bromophenyl)methoxy]quinazoline
CAS Number737818-56-3
PubChem CID2368291
IUPAC Name4-[(4-bromophenyl)methoxy]quinazoline
Molecular FormulaC15H11BrN2O
Molecular Weight315.16
XLogP4.2
Topological Polar Surface Area35
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count19
Formal Charge0
Complexity281
SMILES
C1=CC=C2C(=C1)C(=NC=N2)OCC3=CC=C(C=C3)Br
InChI
InChI=1S/C15H11BrN2O/c16-12-7-5-11(6-8-12)9-19-15-13-3-1-2-4-14(13)17-10-18-15/h1-8,10H,9H2
InChIKey
DADJIQURPZZXBT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-[(4-Bromophenyl)methoxy]quinazoline
CAS: 737818-56-3
CID: 2368291
Formula: C15H11BrN2O
MW: 315.16
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight315.16
XLogP34.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass314.00548
Monoisotopic Mass314.00548
Topological Polar Surface Area35 Ų
Heavy Atom Count19
Formal Charge0
Complexity281
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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