EGFR/VEGFR2-IN-4

• UNSPSC Description:

  EGFR/VEGFR2-IN-4 (Compound 19) is the irreversible inhibitor for EGFR and VEGFR-2 with IC50 of 18.7 nM and 102.3 nM, under the presence of 1 μM ATP[1].

• Target Antigen:

  EGFR; VEGFR

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling;Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/egfr-vegfr2-in-4.html

• Smiles:

  CCOC(C(NC(/C=C/CN(C)C)=O)=C1)=CC2=C1C(NC(C(C=C3OCC4=CC=CC=C4)=O)=CC3=O)=NC=N2

• Molecular Weight:

  527.57

• References & Citations:

  [1]Wissner A, et al., Dual irreversible kinase inhibitors: quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2. Bioorg Med Chem. 2007 Jun 1;15(11):3635-48.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  870962-74-6