Anticancer agent 191

• Description:

  Anticancer agent 191 (Compound 2) is a derivative of probenecid (HY-B0545) . As a cancer cell efflux inhibitor, Anticancer agent 191 is designed to inhibit P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and/or multiple multidrug resistance proteins (MRPs) . Anticancer agent 191 increases the accumulation of vinblastine in cancer cells, which is used for cancer research[1].

• UNSPSC:

  12352005

• Target:

  BCRP; P-glycoprotein

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/anticancer-agent-191.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCCN(S(=O)(C1=CC=C(C=C1)C(NCCCC[C@H](C(O)=O)N)=O)=O)CCC

• Molecular Formula:

  C19H31N3O5S

• Molecular Weight:

  413.53

• References & Citations:

  [1]Huttunen J, et al. Amino acid derivative of probenecid potentiates apoptosis-inducing effects of vinblastine by increasing oxidative stress in a cancer cell-specific manner. Chem Biol Interact. 2024 Jan 25;388:110833.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [9007-83-4]